The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release

The myeloid inhibitory C-type lectin receptor CLEC12A limits neutrophil activation, pro-inflammatory pathways and disease in mouse models of inflammatory arthritis by a molecular mechanism that remains poorly understood. We addressed how CLEC12A-mediated inhibitory signaling counteracts activating s...

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Detalles Bibliográficos
Autores principales: Paré, Guillaume, Vitry, Julien, Merchant, Michael L., Vaillancourt, Myriam, Murru, Andréa, Shen, Yunyun, Elowe, Sabine, Lahoud, Mireille H., Naccache, Paul H., McLeish, Kenneth R., Fernandes, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256872/
https://www.ncbi.nlm.nih.gov/pubmed/34234773
http://dx.doi.org/10.3389/fimmu.2021.650808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256872/
https://www.ncbi.nlm.nih.gov/pubmed/34234773
http://dx.doi.org/10.3389/fimmu.2021.650808

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