Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers

Several opioids are metabolized by the inducible cytochrome P450 (CYP) 3A isozymes. Coadministration with strong inducers of drug metabolism, such as rifampin, can dramatically reduce systemic exposure to these opioids. As the CYP metabolism of hydromorphone is of minor importance, we studied in hea...

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Detalles Bibliográficos
Autores principales: Lohela, Terhi J., Poikola, Satu, Neuvonen, Mikko, Niemi, Mikko, Backman, Janne T., Olkkola, Klaus T., Lilius, Tuomas O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkin 2020
Materias:
48
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257471/
https://www.ncbi.nlm.nih.gov/pubmed/33177323
http://dx.doi.org/10.1213/ANE.0000000000005229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257471/
https://www.ncbi.nlm.nih.gov/pubmed/33177323
http://dx.doi.org/10.1213/ANE.0000000000005229

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