Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination

To clarify whether differential compartmentalization of Survivin impacts temozolomide (TMZ)-triggered end points, we established a well-defined glioblastoma cell model in vitro (LN229 and A172) and in vivo, distinguishing between its nuclear and cytoplasmic localization. Expression of nuclear export...

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Detalles Bibliográficos
Autores principales: Reich, Thomas R., Schwarzenbach, Christian, Vilar, Juliana Brandstetter, Unger, Sven, Mühlhäusler, Fabian, Nikolova, Teodora, Poplawski, Alicia, Baymaz, H. Irem, Beli, Petra, Christmann, Markus, Tomicic, Maja T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257519/
https://www.ncbi.nlm.nih.gov/pubmed/34100981
http://dx.doi.org/10.1007/s00018-021-03864-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257519/
https://www.ncbi.nlm.nih.gov/pubmed/34100981
http://dx.doi.org/10.1007/s00018-021-03864-0

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