Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells

Glutathione peroxidase (GPx) is a selenocysteine-containing peroxidase enzyme that defends mammalian cells against oxidative stress, but the role of GPx signaling is poorly characterized. Here, we show that GPx type 1 (GPx1) plays a key regulatory role in the apoptosis signaling pathway. The absence...

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Detalles Bibliográficos
Autores principales: Lee, Sunmi, Lee, Eun-Kyung, Kang, Dong Hoon, Lee, Jiyoung, Hong, Soo Hyun, Jeong, Woojin, Kang, Sang Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257591/
https://www.ncbi.nlm.nih.gov/pubmed/34158609
http://dx.doi.org/10.1038/s12276-021-00642-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257591/
https://www.ncbi.nlm.nih.gov/pubmed/34158609
http://dx.doi.org/10.1038/s12276-021-00642-7

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