DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis

Alternative promoter usage generates long and short isoforms (DCLK1-L and DCLK1-S) of doublecortin-like kinase-1 (DCLK1). Tight control of Notch signaling is important to prevent and restitute inflammation in the intestine. Our aim was to investigate whether Notch1–DCLK1 axis regulates the mucosal i...

Descripción completa

Detalles Bibliográficos
Autores principales: Roy, Badal C., Ahmed, Ishfaq, Stubbs, Jason, Zhang, Jun, Attard, Thomas, Septer, Seth, Welch, Danny, Anant, Shrikant, Sampath, Venkatesh, Umar, Shahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257684/
https://www.ncbi.nlm.nih.gov/pubmed/34226497
http://dx.doi.org/10.1038/s41420-021-00526-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257684/
https://www.ncbi.nlm.nih.gov/pubmed/34226497
http://dx.doi.org/10.1038/s41420-021-00526-9

Ejemplares similares