DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes

DNA glycosylases must distinguish the sparse damaged sites from the vast expanse of normal DNA bases. However, our understanding of the nature of nucleobase interrogation is still limited. Here, we show that hNEIL1 (human endonuclease VIII-like 1) captures base lesions via two competing states of in...

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Detalles Bibliográficos
Autores principales: Liu, Menghao, Zhang, Jun, Zhu, Chenxu, Zhang, Xiaoxue, Xiao, Weide, Yan, Yongchang, Liu, Lulu, Zeng, Hu, Gao, Yi Qin, Yi, Chengqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257757/
https://www.ncbi.nlm.nih.gov/pubmed/34226550
http://dx.doi.org/10.1038/s41467-021-24431-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257757/
https://www.ncbi.nlm.nih.gov/pubmed/34226550
http://dx.doi.org/10.1038/s41467-021-24431-y

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