A synthetic circuit for buffering gene dosage variation between individual mammalian cells

Precise control of gene expression is critical for biological research and biotechnology. However, transient plasmid transfections in mammalian cells produce a wide distribution of copy numbers per cell, and consequently, high expression heterogeneity. Here, we report plasmid-based synthetic circuit...

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Detalles Bibliográficos
Autores principales: Yang, Jin, Lee, Jihwan, Land, Michelle A., Lai, Shujuan, Igoshin, Oleg A., St-Pierre, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257781/
https://www.ncbi.nlm.nih.gov/pubmed/34226556
http://dx.doi.org/10.1038/s41467-021-23889-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257781/
https://www.ncbi.nlm.nih.gov/pubmed/34226556
http://dx.doi.org/10.1038/s41467-021-23889-0

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