Cargando…

Mouse Embryonic Stem Cells Expressing GDNF Show Enhanced Dopaminergic Differentiation and Promote Behavioral Recovery After Grafting in Parkinsonian Rats

Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic neurons (DaNs) of the substantia nigra pars compacta and the decrease of dopamine in the brain. Grafting DaN differentiated from embryonic stem cells (ESCs) has been proposed as an alternative therapy for curr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lara-Rodarte, Rolando, Cortés, Daniel, Soriano, Karla, Carmona, Francia, Rocha, Luisa, Estudillo, Enrique, López-Ornelas, Adolfo, Velasco, Iván
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258349/ https://www.ncbi.nlm.nih.gov/pubmed/34239871 http://dx.doi.org/10.3389/fcell.2021.661656

Ejemplares similares

Semaphorin 3C Released from a Biocompatible Hydrogel Guides and Promotes Axonal Growth of Rodent and Human Dopaminergic Neurons
por: Carballo-Molina, Oscar A., et al.
Publicado: (2016)

Dynamic landscape of chromatin accessibility and transcriptomic changes during differentiation of human embryonic stem cells into dopaminergic neurons
por: Meléndez-Ramírez, César, et al.
Publicado: (2021)

GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease
por: d’Anglemont de Tassigny, Xavier, et al.
Publicado: (2015)

Human Keratinocytes Adopt Neuronal Fates After In Utero Transplantation in the Developing Rat Brain
por: Tenorio-Mina, Andrea, et al.
Publicado: (2021)

NADPH Oxidase and the Degeneration of Dopaminergic Neurons in Parkinsonian Mice
por: Hernandes, Marina S., et al.
Publicado: (2013)

Conditioned Medium Protects Dopaminergic Neurons in Parkinsonian Rats
por: Nakhaeifard, Malihe, et al.
Publicado: (2018)

Different Dopaminergic Dysfunctions Underlying Parkinsonian Akinesia and Tremor
por: Caligiore, Daniele, et al.
Publicado: (2019)

A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys
por: Ohshima-Hosoyama, Sachiko, et al.
Publicado: (2012)

GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice
por: Chen, Cang, et al.
Publicado: (2018)

MEF2C Enhances Dopaminergic Neuron Differentiation of Human Embryonic Stem Cells in a Parkinsonian Rat Model
por: Cho, Eun-Gyung, et al.
Publicado: (2011)

Calcitriol Imparts Neuroprotection In Vitro to Midbrain Dopaminergic Neurons by Upregulating GDNF Expression
por: Orme, Rowan P., et al.
Publicado: (2013)

The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system
por: Kramer, Edgar R.
Publicado: (2015)

CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes
por: Zhang, Wenlong, et al.
Publicado: (2020)

Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern
por: Kulinski, Tomasz M., et al.
Publicado: (2015)

Transgenic GDNF Positively Influences Proliferation, Differentiation, Maturation and Survival of Motor Neurons Produced from Mouse Embryonic Stem Cells
por: Cortés, Daniel, et al.
Publicado: (2016)

The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons
por: Lu, Xi, et al.
Publicado: (2014)

Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain
por: Tarasova, Tatiana V., et al.
Publicado: (2018)

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
por: Kumar, Anmol, et al.
Publicado: (2015)

Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats
por: Taravini, Irene RE, et al.
Publicado: (2011)

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
por: Tain, Luke S, et al.
Publicado: (2009)

Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System
por: Leem, Eunju, et al.
Publicado: (2016)

Dopaminergic Modulation of Spectral and Spatial Characteristics of Parkinsonian Subthalamic Nucleus Beta Bursts
por: Sure, Matthias, et al.
Publicado: (2021)

Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release
por: Zhang, Feng, et al.
Publicado: (2012)

Correction: GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
por: Kumar, Anmol, et al.
Publicado: (2016)

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits
por: Marton, Soledad, et al.
Publicado: (2019)

Simvastatin Prevents Dopaminergic Neurodegeneration in Experimental Parkinsonian Models: The Association with Anti-Inflammatory Responses
por: Yan, Junqiang, et al.
Publicado: (2011)

22(R)-hydroxycholesterol for dopaminergic neuronal specification of MSCs and amelioration of Parkinsonian symptoms in rats
por: Singh, Manisha, et al.
Publicado: (2021)

Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro
por: Baillie-Johnson, Peter, et al.
Publicado: (2015)

Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice
por: Turconi, Giorgio, et al.
Publicado: (2020)

Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice
por: Sgobio, Carmelo, et al.
Publicado: (2019)

Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes
por: Yang, Hao, et al.
Publicado: (2019)

The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats
por: da Costa, Roberta Oliveira, et al.
Publicado: (2017)

EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0
por: Morbelli, Silvia, et al.
Publicado: (2020)

DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms
por: Seo, Dong-Chan, et al.
Publicado: (2023)

Simultaneous Transplantation of Fetal Ventral Mesencephalic Tissue and Encapsulated Genetically Modified Cells Releasing GDNF in a Hemi-Parkinsonian Rat Model of Parkinson’s Disease
por: Perez-Bouza, Alberto, et al.
Publicado: (2017)

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
por: Mersha, Mahlet D., et al.
Publicado: (2018)

Parkinsonian Rigidity Shows Variable Properties Depending on the Elbow Joint Angle
por: Endo, Takuyuki, et al.
Publicado: (2013)

Corrigendum to “The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats”
por: da Costa, Roberta Oliveira, et al.
Publicado: (2018)

Biochemical Changes Induced by Embryonic Substantia Nigra Transplanted to the Striatum of Parkinsonian Monkeys
por: Elsworth, J. D., et al.
Publicado: (1992)

Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression
por: Gao, J, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_f3e1panmno3bunm7v8lfsfntnr