Binding profile of protein–ligand inhibitor complex and structure based design of new potent compounds via computer-aided virtual screening

BACKGROUND: Mycobacterium tuberculosis protein target (DNA gyrase) is a type II topoisomerase target present in all bacteria. The enzyme comprises of two subunits A and B. DNA binding domain is located in the subunits A while the catalysis and cleavage of two DNA strands occur in the subunits A usin...

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Detalles Bibliográficos
Autores principales: Shallangwa, Gideon Adamu, Adeniji, Shola Elijah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258700/
https://www.ncbi.nlm.nih.gov/pubmed/34307904
http://dx.doi.org/10.1016/j.jctube.2021.100256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258700/
https://www.ncbi.nlm.nih.gov/pubmed/34307904
http://dx.doi.org/10.1016/j.jctube.2021.100256

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