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Binding profile of protein–ligand inhibitor complex and structure based design of new potent compounds via computer-aided virtual screening
BACKGROUND: Mycobacterium tuberculosis protein target (DNA gyrase) is a type II topoisomerase target present in all bacteria. The enzyme comprises of two subunits A and B. DNA binding domain is located in the subunits A while the catalysis and cleavage of two DNA strands occur in the subunits A usin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258700/ https://www.ncbi.nlm.nih.gov/pubmed/34307904 http://dx.doi.org/10.1016/j.jctube.2021.100256 |