Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver

BACKGROUND & AIMS: Fatty liver or nonalcoholic fatty liver disease (NAFLD) is the most common liver disease associated with comorbidities such as insulin resistance and cardiovascular and metabolic diseases. Chronic activation of hypoxic signaling, in particular, hypoxia-inducible factor (HIF)2α...

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Detalles Bibliográficos
Autores principales: Mooli, Raja Gopal Reddy, Rodriguez, Jessica, Takahashi, Shogo, Solanki, Sumeet, Gonzalez, Frank J., Ramakrishnan, Sadeesh K., Shah, Yatrik M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258975/
https://www.ncbi.nlm.nih.gov/pubmed/33798787
http://dx.doi.org/10.1016/j.jcmgh.2021.03.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258975/
https://www.ncbi.nlm.nih.gov/pubmed/33798787
http://dx.doi.org/10.1016/j.jcmgh.2021.03.011

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