Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

Yes-associated Protein (YAP) is a transcriptional co-activator that regulates cell proliferation and survival by binding to a select set of enhancers for target gene activation. How YAP coordinates these transcriptional responses is unknown. Here, we demonstrate that YAP forms liquid-like condensate...

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Detalles Bibliográficos
Autores principales: Cai, Danfeng, Feliciano, Daniel, Dong, Peng, Flores, Eduardo, Gruebele, Martin, Porat-Shliom, Natalie, Sukenik, Shahar, Liu, Zhe, Lippincott-Schwartz, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259329/
https://www.ncbi.nlm.nih.gov/pubmed/31792379
http://dx.doi.org/10.1038/s41556-019-0433-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259329/
https://www.ncbi.nlm.nih.gov/pubmed/31792379
http://dx.doi.org/10.1038/s41556-019-0433-z

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