Cargando…

The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches

BACKGROUND: Candidemia is one of the most common nosocomial bloodstream infections in the United States, causing significant morbidity and mortality in hospitalized patients, but the breadth of the host response to Candida infections in human patients remains poorly defined. METHODS: In order to bet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steinbrink, Julie M., Myers, Rachel A., Hua, Kaiyuan, Johnson, Melissa D., Seidelman, Jessica L., Tsalik, Ephraim L., Henao, Ricardo, Ginsburg, Geoffrey S., Woods, Christopher W., Alexander, Barbara D., McClain, Micah T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259367/ https://www.ncbi.nlm.nih.gov/pubmed/34225776 http://dx.doi.org/10.1186/s13073-021-00924-9

Ejemplares similares

2885. A Host Transcriptional Signature for Accurate Diagnosis of Candidemia in the Hospital Setting
por: Steinbrink, Julie M, et al.
Publicado: (2019)

305. PBMC-Derived Transcriptomic Signatures Accurately Discriminate Between Viral, Bacterial, and Fungal Infections and can be Translated to Real-World Human Infections
por: Steinbrink, Julie M, et al.
Publicado: (2023)

1330. Evaluation of Multiple Host Response-Based Strategies to Classify Acute Respiratory Illness
por: Ross, Melissa H, et al.
Publicado: (2019)

1226. Performance of a Host Response Test for Bacterial/Viral Discrimination in Immunocompromised Patients
por: Mahle, Rachael E, et al.
Publicado: (2020)

Systematic comparison of published host gene expression signatures for bacterial/viral discrimination
por: Bodkin, Nicholas, et al.
Publicado: (2022)

A comparison of host response strategies to distinguish bacterial and viral infection
por: Ross, Melissa, et al.
Publicado: (2021)

2595. Murine Models for the Host Response to Typical and Atypical Pneumonia
por: Khan, Kirin, et al.
Publicado: (2019)

1218. Comparing the Diagnostic Accuracy of Clinician Judgement to a Novel Host Response Diagnostic for Acute Respiratory Illness
por: Jaffe, Ian S, et al.
Publicado: (2020)

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approaches
por: McClain, Micah T., et al.
Publicado: (2020)

A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies
por: Poore, Gregory D., et al.
Publicado: (2018)

2014. TLDA Validation of a Host Response Signature to Discriminate Bacterial, Viral, and Non-infectious Causes of Illness
por: Lydon, Emily, et al.
Publicado: (2018)

2015. Host Gene Expression Identifies Infectious Triggers of Asthma Exacerbation
por: Lydon, Emily, et al.
Publicado: (2018)

A host gene expression approach for identifying triggers of asthma exacerbations
por: Lydon, Emily C., et al.
Publicado: (2019)

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery
por: McClain, Micah T., et al.
Publicado: (2021)

2012. FilmArray(®) Measurement of Host Response Signatures RapidLy Discriminates Viral, Bacterial, and Non-infectious Etiologies of Illness
por: Tsalik, Ephraim L, et al.
Publicado: (2018)

Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset
por: Grzesiak, Emilia, et al.
Publicado: (2021)

A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study
por: McClain, Micah T, et al.
Publicado: (2021)

Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population
por: Tillekeratne, L Gayani, et al.
Publicado: (2020)

Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection
por: Burke, Thomas W., et al.
Publicado: (2017)

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
por: Wang, Liuyang, et al.
Publicado: (2020)

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
por: Wang, Liuyang, et al.
Publicado: (2021)

The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood
por: Tsalik, Ephraim L., et al.
Publicado: (2021)

Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing
por: Limkakeng, Alexander T., et al.
Publicado: (2019)

2018. Host Gene Expression Classifiers Distinguish Bacterial and Viral Infections in Sri Lankan Patients with Acute Febrile Respiratory Illness
por: Gayani Tillekeratne, L, et al.
Publicado: (2018)

A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses
por: McClain, Micah T., et al.
Publicado: (2016)

SARS‐CoV‐2 reinfection across a spectrum of immunological states
por: McKittrick, Justine M., et al.
Publicado: (2022)

Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity
por: Giroux, Nicholas S., et al.
Publicado: (2020)

Validation of a host response test to distinguish bacterial and viral respiratory infection
por: Lydon, Emily C., et al.
Publicado: (2019)

1023. Host Gene Expression Biomarkers to Distinguish Between Causes of Acute Respiratory Symptoms in Lung Transplant Recipients
por: Steinbrink, Julie M, et al.
Publicado: (2021)

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion
por: Giroux, Nicholas S., et al.
Publicado: (2022)

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion
por: Giroux, Nicholas S., et al.
Publicado: (2022)

Author Correction: Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion
por: Giroux, Nicholas S., et al.
Publicado: (2023)

1721. A Transcriptional Signature of Acute Aspergillus Infection Offers High Diagnostic Accuracy Despite the Presence of Immunosuppression
por: Steinbrink, Julie M, et al.
Publicado: (2019)

1216. Benchmarking Published Gene Signatures for Robust Infection Classification
por: Bodkin, Nicholas, et al.
Publicado: (2020)

A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection
por: Fourati, Slim, et al.
Publicado: (2018)

An integrated transcriptome and expressed variant analysis of sepsis survival and death
por: Tsalik, Ephraim L, et al.
Publicado: (2014)

Transcriptional responses define dysregulated immune activation in Hepatitis C (HCV)-naïve recipients of HCV-infected donor kidneys
por: Steinbrink, Julie M., et al.
Publicado: (2023)

Heme biosynthesis and its regulation: towards understanding and improvement of heme biosynthesis in filamentous fungi
por: Franken, Angelique C. W., et al.
Publicado: (2011)

Plasmodium heme biosynthesis: To be or not to be essential?
por: Goldberg, Daniel E., et al.
Publicado: (2017)

Erythropoietin signaling regulates heme biosynthesis
por: Chung, Jacky, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e11tdus2pi60et7a1v5h0qppqo