The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease characterized by the formation of cytoplasmic ubiquitinated TDP-43 protein aggregates in motor neurons. Stress granules (SGs) are stress-induced cytoplasmic protein aggregates containing various neuropathogenic proteins, incl...

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Detalles Bibliográficos
Autores principales: Kakihana, Taichi, Takahashi, Masahiko, Katsuragi, Yoshinori, Yamashita, Shun-Ichi, Sango, Junya, Kanki, Tomotake, Onodera, Osamu, Fujii, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259439/
https://www.ncbi.nlm.nih.gov/pubmed/34258561
http://dx.doi.org/10.1016/j.isci.2021.102733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259439/
https://www.ncbi.nlm.nih.gov/pubmed/34258561
http://dx.doi.org/10.1016/j.isci.2021.102733

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