Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme

A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b–2d, 3a–3d, and 4a–4c were active against the H37Rv-...

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Detalles Bibliográficos
Autores principales: Venugopala, Katharigatta N., Chandrashekharappa, Sandeep, Deb, Pran Kishore, Tratrat, Christophe, Pillay, Melendhran, Chopra, Deepak, Al-Shar’i, Nizar A., Hourani, Wafa, Dahabiyeh, Lina A., Borah, Pobitra, Nagdeve, Rahul D., Nayak, Susanta K., Padmashali, Basavaraj, Morsy, Mohamed A., Aldhubiab, Bandar E., Attimarad, Mahesh, Nair, Anroop B., Sreeharsha, Nagaraja, Haroun, Michelyne, Shashikanth, Sheena, Mohanlall, Viresh, Mailavaram, Raghuprasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259857/
https://www.ncbi.nlm.nih.gov/pubmed/34210233
http://dx.doi.org/10.1080/14756366.2021.1919889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259857/
https://www.ncbi.nlm.nih.gov/pubmed/34210233
http://dx.doi.org/10.1080/14756366.2021.1919889

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