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Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme
A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b–2d, 3a–3d, and 4a–4c were active against the H37Rv-...
Autores principales: | Venugopala, Katharigatta N., Chandrashekharappa, Sandeep, Deb, Pran Kishore, Tratrat, Christophe, Pillay, Melendhran, Chopra, Deepak, Al-Shar’i, Nizar A., Hourani, Wafa, Dahabiyeh, Lina A., Borah, Pobitra, Nagdeve, Rahul D., Nayak, Susanta K., Padmashali, Basavaraj, Morsy, Mohamed A., Aldhubiab, Bandar E., Attimarad, Mahesh, Nair, Anroop B., Sreeharsha, Nagaraja, Haroun, Michelyne, Shashikanth, Sheena, Mohanlall, Viresh, Mailavaram, Raghuprasad |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259857/ https://www.ncbi.nlm.nih.gov/pubmed/34210233 http://dx.doi.org/10.1080/14756366.2021.1919889 |
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