Spike protein cleavage-activation in the context of the SARS-CoV-2 P681R mutation: an analysis from its first appearance in lineage A.23.1 identified in Uganda

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Based on its predicted ability to affect transmissibility and pathogenesis, surveillance studies have highlighted the role of a specific mutation (P681R) in the S1/S2 furin cleavage site of the SARS-CoV-2 spike protein. Here we analyzed A.23.1, first identified in Uganda, as a P681R-containing virus...

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Detalles Bibliográficos
Autores principales: Lubinski, Bailey, Frazier, Laura E., Phan, My V.T., Bugembe, Daniel L., Cunningham, Jessie L., Tang, Tiffany, Daniel, Susan, Cotten, Matthew, Jaimes, Javier A., Whittaker, Gary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259907/
https://www.ncbi.nlm.nih.gov/pubmed/34230931
http://dx.doi.org/10.1101/2021.06.30.450632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259907/
https://www.ncbi.nlm.nih.gov/pubmed/34230931
http://dx.doi.org/10.1101/2021.06.30.450632

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