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Cadherin-11 Deficiency Attenuates Ang-II-Induced Atrial Fibrosis and Susceptibility to Atrial Fibrillation

BACKGROUND: Atrial fibrosis serves as a disease initiating mechanism in the development of atrial fibrillation. Angiotensin II (Ang-II), a key mediator for atrial fibrosis, aberrantly activates atrial fibroblasts (AFs) into myofibroblasts, resulting in subsequent excessive synthesis and deposition o...

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Detalles Bibliográficos
Autores principales: Cao, Wei, Song, Shuai, Fang, Guojian, Li, Yingze, Wang, Yuepeng, Wang, Qun-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259948/
https://www.ncbi.nlm.nih.gov/pubmed/34239314
http://dx.doi.org/10.2147/JIR.S306073