Development, maturation, and maintenance of human prostate inferred from somatic mutations

Clonal dynamics and mutation burden in healthy human prostate epithelium are relevant to prostate cancer. We sequenced whole genomes from 409 microdissections of normal prostate epithelium across 8 donors, using phylogenetic reconstruction with spatial mapping in a 59-year-old man’s prostate to reco...

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Detalles Bibliográficos
Autores principales: Grossmann, Sebastian, Hooks, Yvette, Wilson, Laura, Moore, Luiza, O’Neill, Laura, Martincorena, Iñigo, Voet, Thierry, Stratton, Michael R., Heer, Rakesh, Campbell, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260206/
https://www.ncbi.nlm.nih.gov/pubmed/33657416
http://dx.doi.org/10.1016/j.stem.2021.02.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260206/
https://www.ncbi.nlm.nih.gov/pubmed/33657416
http://dx.doi.org/10.1016/j.stem.2021.02.005

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