An MDM2 inhibitor achieves synergistic cytotoxic effects with adenoviruses lacking E1B55kDa gene on mesothelioma with the wild-type p53 through augmenting NFI expression

A majority of mesothelioma specimens were defective of p14 and p16 expression due to deletion of the INK4A/ARF region, and the p53 pathway was consequently inactivated by elevated MDM2 functions which facilitated p53 degradaton. We investigated a role of p53 elevation by MDM2 inhibitors, nutlin-3a a...

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Detalles Bibliográficos
Autores principales: Nguyen, Thao Thi Thanh, Shingyoji, Masato, Hanazono, Michiko, Zhong, Boya, Morinaga, Takao, Tada, Yuji, Shimada, Hideaki, Hiroshima, Kenzo, Tagawa, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260618/
https://www.ncbi.nlm.nih.gov/pubmed/34230456
http://dx.doi.org/10.1038/s41419-021-03934-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260618/
https://www.ncbi.nlm.nih.gov/pubmed/34230456
http://dx.doi.org/10.1038/s41419-021-03934-y

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