EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer

The TMPRSS2-ERG gene fusion is the most frequent alteration observed in human prostate cancer. However, its role in disease progression is still unclear. In this study, we uncover an important mechanism promoting ERG oncogenic activity. We show that ERG is methylated by Enhancer of zest homolog 2 (E...

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Detalles Bibliográficos
Autores principales: Zoma, Marita, Curti, Laura, Shinde, Dheeraj, Albino, Domenico, Mitra, Abhishek, Sgrignani, Jacopo, Mapelli, Sarah N., Sandrini, Giada, Civenni, Gianluca, Merulla, Jessica, Chiorino, Giovanna, Kunderfranco, Paolo, Cacciatore, Alessia, Kokanovic, Aleksandra, Rinaldi, Andrea, Cavalli, Andrea, Catapano, Carlo V., Carbone, Giuseppina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260656/
https://www.ncbi.nlm.nih.gov/pubmed/34230470
http://dx.doi.org/10.1038/s41467-021-24380-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260656/
https://www.ncbi.nlm.nih.gov/pubmed/34230470
http://dx.doi.org/10.1038/s41467-021-24380-6

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