Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins

Prenylated indole alkaloids featuring spirooxindole rings possess a 3R or 3S carbon stereocenter, which determines the bioactivities of these compounds. Despite the stereoselective advantages of spirooxindole biosynthesis compared with those of organic synthesis, the biocatalytic mechanism for contr...

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Detalles Bibliográficos
Autores principales: Liu, Zhiwen, Zhao, Fanglong, Zhao, Boyang, Yang, Jie, Ferrara, Joseph, Sankaran, Banumathi, Venkataram Prasad, B. V., Kundu, Biki Bapi, Phillips, George N., Gao, Yang, Hu, Liya, Zhu, Tong, Gao, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260726/
https://www.ncbi.nlm.nih.gov/pubmed/34230497
http://dx.doi.org/10.1038/s41467-021-24421-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260726/
https://www.ncbi.nlm.nih.gov/pubmed/34230497
http://dx.doi.org/10.1038/s41467-021-24421-0

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