Targeting of SET/I2PP2A oncoprotein inhibits Gli1 transcription revealing a new modulator of Hedgehog signaling

The Hedgehog (Hh)/Gli signaling pathway controls cell proliferation and differentiation, is critical for the development of nearly every tissue and organ in vertebrates and is also involved in tumorigenesis. In this study, we characterize the oncoprotein SET/I2PP2A as a novel regulator of Hh signali...

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Detalles Bibliográficos
Autores principales: Serifi, Iliana, Besta, Simoni, Karetsou, Zoe, Giardoglou, Panagiota, Beis, Dimitris, Niewiadomski, Pawel, Papamarcaki, Thomais
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260731/
https://www.ncbi.nlm.nih.gov/pubmed/34230583
http://dx.doi.org/10.1038/s41598-021-93440-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260731/
https://www.ncbi.nlm.nih.gov/pubmed/34230583
http://dx.doi.org/10.1038/s41598-021-93440-0

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