A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells

HER3 is a member of the EGF receptor family and elevated expression is associated with cancer progression and therapy resistance. HER3-specific T-cell engagers might be a suitable treatment option to circumvent the limited efficacy observed for HER3-blocking antibodies in clinical trials. In this st...

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Detalles Bibliográficos
Autores principales: Aschmoneit, Nadine, Steinlein, Sophia, Kühl, Lennart, Seifert, Oliver, Kontermann, Roland E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260734/
https://www.ncbi.nlm.nih.gov/pubmed/34230555
http://dx.doi.org/10.1038/s41598-021-93351-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260734/
https://www.ncbi.nlm.nih.gov/pubmed/34230555
http://dx.doi.org/10.1038/s41598-021-93351-0

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