Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity

Human induced pluripotent stem (iPS) cell technologies coupled with genetic engineering now facilitate the study of the molecular underpinnings of disease in relevant human cell types. Application of CRISPR/Cas9-based approaches for genome-scale functional screening in iPS-derived cells, however, ha...

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Detalles Bibliográficos
Autores principales: Sapp, Valerie, Aguirre, Aitor, Mainkar, Gayatri, Ding, Jeffrey, Adler, Eric, Liao, Ronglih, Sharma, Sonia, Jain, Mohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260754/
https://www.ncbi.nlm.nih.gov/pubmed/34230586
http://dx.doi.org/10.1038/s41598-021-92988-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260754/
https://www.ncbi.nlm.nih.gov/pubmed/34230586
http://dx.doi.org/10.1038/s41598-021-92988-1

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