A Functional Variant Rs492554 Associated With Congenital Heart Defects Modulates SESN2 Expression Through POU2F1

Hypoxia exposure is responsible for the high incidence of congenital heart defects (CHDs) in high-altitude areas, which is nearly 20 times higher than that in low-altitude areas. However, the genetic factors involved are rarely reported. Sestrin2 (SESN2), a hypoxia stress-inducible gene, protects ca...

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Detalles Bibliográficos
Autores principales: Yang, Wenke, Li, Yi, Bai, Jun, You, Tao, Yi, Kang, Xie, Dingxiong, Zhang, Xiaowei, Xie, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260953/
https://www.ncbi.nlm.nih.gov/pubmed/34249922
http://dx.doi.org/10.3389/fcell.2021.668474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260953/
https://www.ncbi.nlm.nih.gov/pubmed/34249922
http://dx.doi.org/10.3389/fcell.2021.668474

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