MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription

Death receptor 4 (DR4) is a cell surface protein that is generally thought to mediate apoptosis upon binding to its ligand named TRAIL. However, its contribution to apoptosis resistance has also been reported. MET (or c-MET) gene amplification represents an important mechanism for acquired resistanc...

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Detalles Bibliográficos
Autores principales: Deng, Liang, Vallega, Karin A., Zhang, Shuo, Shi, Puyu, Sun, Shi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260959/
https://www.ncbi.nlm.nih.gov/pubmed/34233230
http://dx.doi.org/10.1016/j.neo.2021.06.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260959/
https://www.ncbi.nlm.nih.gov/pubmed/34233230
http://dx.doi.org/10.1016/j.neo.2021.06.006

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