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Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK

Since Dr. Ogden Bruton’s 1952 paper describing the first human primary immunodeficiency disease, the peripheral membrane binding signaling protein, aptly named Bruton’s tyrosine kinase (BTK), has been the target of intense study. Dr. Bruton’s description of agammaglobulinemia set the stage for ultim...

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Detalles Bibliográficos
Autores principales: Kueffer, Lauren E., Joseph, Raji E., Andreotti, Amy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260988/
https://www.ncbi.nlm.nih.gov/pubmed/34249912
http://dx.doi.org/10.3389/fcell.2021.655489