pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages for enhanced MDR reversal and chemotherapy

TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance (MDR) and as an anticancer agent for synergistic antitumor effects. However, the comparatively high critical micelle concentration (CMC), low drug loading (DL) and poor tumor target limit its further cl...

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Detalles Bibliográficos
Autores principales: Xu, Yong, Wang, Shi, Yang, Longshun, Dong, Yuhang, Zhang, Yafang, Yan, Guoqing, Tang, Rupei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2021
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261081/
https://www.ncbi.nlm.nih.gov/pubmed/34276824
http://dx.doi.org/10.1016/j.ajps.2021.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261081/
https://www.ncbi.nlm.nih.gov/pubmed/34276824
http://dx.doi.org/10.1016/j.ajps.2021.01.002

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