Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice

OBJECTIVE: The contribution of sustained autologous autoantibody production by B cells to the pathogenesis of systemic sclerosis (SSc) and granulomatosis with polyangiitis (GPA) is not fully understood. To investigate this, a humanized mouse model was generated by transferring patient-derived periph...

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Detalles Bibliográficos
Autores principales: Yue, Xiaoyang, Petersen, Frank, Shu, Yaqing, Kasper, Brigitte, Magatsin, Junie D. Tchudjin, Ahmadi, Marjan, Yin, Junping, Wax, Jacqueline, Wang, Xiaoqing, Heidecke, Harald, Lamprecht, Peter, Müller, Antje, Yu, Xinhua, Riemekasten, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261241/
https://www.ncbi.nlm.nih.gov/pubmed/34248959
http://dx.doi.org/10.3389/fimmu.2021.677970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261241/
https://www.ncbi.nlm.nih.gov/pubmed/34248959
http://dx.doi.org/10.3389/fimmu.2021.677970

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