Cargando…

Synaptic disruption and CREB‐regulated transcription are restored by K(+) channel blockers in ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing effective therapeutic strategies. Although manipulation of neuronal excitability has been tested in murine and human ALS models, it is still under debate whether neuronal activity might represent a valid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Catanese, Alberto, Rajkumar, Sandeep, Sommer, Daniel, Freisem, Dennis, Wirth, Alexander, Aly, Amr, Massa‐López, David, Olivieri, Andrea, Torelli, Federica, Ioannidis, Valentin, Lipecka, Joanna, Guerrera, Ida Chiara, Zytnicki, Daniel, Ludolph, Albert, Kabashi, Edor, Mulaw, Medhanie A, Roselli, Francesco, Böckers, Tobias M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261490/ https://www.ncbi.nlm.nih.gov/pubmed/34125498 http://dx.doi.org/10.15252/emmm.202013131

Ejemplares similares

Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis
por: Catanese, Alberto, et al.
Publicado: (2023)

Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models
por: Seidel, Mira, et al.
Publicado: (2023)

Correction to: Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
por: Aly, Amr, et al.
Publicado: (2023)

Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
por: Aly, Amr, et al.
Publicado: (2023)

Fast and efficient synaptosome isolation and post-synaptic density enrichment from hiPSC-motor neurons by biochemical sub-cellular fractionation
por: Rajkumar, Sandeep, et al.
Publicado: (2023)

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons
por: Sommer, Daniel, et al.
Publicado: (2022)

Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines
por: Lissouba, Alexandra, et al.
Publicado: (2018)

Diagnostic Challenge and Neuromuscular Junction Contribution to ALS Pathogenesis
por: Campanari, Maria-Letizia, et al.
Publicado: (2019)

Novel genome-editing-based approaches to treat motor neuron diseases: Promises and challenges
por: Miccio, Annarita, et al.
Publicado: (2022)

TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish
por: Campanari, Maria-Letizia, et al.
Publicado: (2021)

Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
por: Matteini, Francesca, et al.
Publicado: (2021)

Novel perspective on field recordings in zebrafish models of epilepsy
por: Dabacan, Adriana, et al.
Publicado: (2015)

Freezing activity brief data from a new FUS mutant zebrafish line
por: Campanari, Maria-Letizia, et al.
Publicado: (2020)

Autophagy and ALS: mechanistic insights and therapeutic implications
por: Chua, Jason P., et al.
Publicado: (2021)

Low T-cell reactivity to TDP-43 peptides in ALS
por: Ramachandran, Swetha, et al.
Publicado: (2023)

The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway
por: Ciura, Sorana, et al.
Publicado: (2016)

Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury
por: Rehman, Rida, et al.
Publicado: (2021)

Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients
por: Bayer, David, et al.
Publicado: (2021)

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase
por: Campanari, Maria-Letizia, et al.
Publicado: (2016)

FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis
por: Kabashi, Edor, et al.
Publicado: (2011)

Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins
por: Yilmaz, Ayse, et al.
Publicado: (2023)

Fishing for causes and cures of motor neuron disorders
por: Patten, Shunmoogum A., et al.
Publicado: (2014)

Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish
por: Demy, Doris Lou, et al.
Publicado: (2020)

ALS is imprinted in the chromatin accessibility of blood cells
por: Kühlwein, Julia K., et al.
Publicado: (2023)

Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio
por: Vaccaro, Alexandra, et al.
Publicado: (2012)

Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells
por: Grigoryan, Ani, et al.
Publicado: (2021)

Is hyperexcitability really guilty in amyotrophic lateral sclerosis?
por: Leroy, Felix, et al.
Publicado: (2015)

Shank3 related muscular hypotonia is accompanied by increased intracellular calcium concentrations and ion channel dysregulation in striated muscle tissue
por: Yildiz, Berra, et al.
Publicado: (2023)

Dataset of a comparative proteomics experiment in a methylmalonyl-CoA mutase knockout HEK 293 cell model
por: Costanzo, Michele, et al.
Publicado: (2020)

Proteomics Reveals that Methylmalonyl-CoA Mutase Modulates Cell Architecture and Increases Susceptibility to Stress
por: Costanzo, Michele, et al.
Publicado: (2020)

A time-resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growth
por: Grinhagens, Sören, et al.
Publicado: (2020)

Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease
por: Jesse, Sarah, et al.
Publicado: (2017)

Deep phenotyping unstructured data mining in an extensive pediatric database to unravel a common KCNA2 variant in neurodevelopmental syndromes
por: Hully, Marie, et al.
Publicado: (2021)

Identification and Relative Quantification of hFSH Glycoforms in Women’s Sera via MS–PRM-Based Approach
por: Melchiorre, Chiara, et al.
Publicado: (2021)

Cross-Reactivity and Functionality of Approved Human Immune Checkpoint Blockers in Dogs
por: Pantelyushin, Stanislav, et al.
Publicado: (2021)

The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons
por: Manuel, Marin, et al.
Publicado: (2014)

Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?
por: Bączyk, Marcin, et al.
Publicado: (2021)

Carvedilol, an Adrenergic Blocker, Suppresses Melanin Synthesis by Inhibiting the cAMP/CREB Signaling Pathway in Human Melanocytes and Ex Vivo Human Skin Culture
por: Choi, Myoung Eun, et al.
Publicado: (2020)

Dataset of differential lipid raft and global proteomes of SILAC-labeled cystic fibrosis cells upon TNF -α stimulation
por: Chhuon, C., et al.
Publicado: (2016)

Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
por: Martínez-Silva, María de Lourdes, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_joipokunc9b3psrqhqsjufcfbv