Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor‐tyrosine‐kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature. Using genetic and chemical approaches t...

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Detalles Bibliográficos
Autores principales: Wang, Yuyi, Salvucci, Ombretta, Ohnuki, Hidetaka, Tran, Andy D, Ha, Taekyu, Feng, Jing‐Xin, DiPrima, Michael, Kwak, Hyeongil, Wang, Dunrui, Yu, Yanlin, Kruhlak, Michael, Tosato, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261520/
https://www.ncbi.nlm.nih.gov/pubmed/34102002
http://dx.doi.org/10.15252/emmm.202114089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261520/
https://www.ncbi.nlm.nih.gov/pubmed/34102002
http://dx.doi.org/10.15252/emmm.202114089

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