Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin

Bivalent chromatin is characterized by occupation of both activating and repressive histone modifications. Here, we develop a mathematical model that involves antagonistic histone modifications H3K4me3 and H3K27me3 to capture the key features of bivalent chromatin. Three necessary conditions for the...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Wei, Qiao, Lingxia, Yan, Shiyu, Nie, Qing, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261666/
https://www.ncbi.nlm.nih.gov/pubmed/34278251
http://dx.doi.org/10.1016/j.isci.2021.102732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261666/
https://www.ncbi.nlm.nih.gov/pubmed/34278251
http://dx.doi.org/10.1016/j.isci.2021.102732

Ejemplares similares