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Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin
Bivalent chromatin is characterized by occupation of both activating and repressive histone modifications. Here, we develop a mathematical model that involves antagonistic histone modifications H3K4me3 and H3K27me3 to capture the key features of bivalent chromatin. Three necessary conditions for the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261666/ https://www.ncbi.nlm.nih.gov/pubmed/34278251 http://dx.doi.org/10.1016/j.isci.2021.102732 |