Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods

An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of several synthetic methods: (1) complexation-driven selective acyl migration/oxidation; (2) BSA-mediated cycli...

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Detalles Bibliográficos
Autores principales: Klapars, Artis, Chung, John Y. L., Limanto, John, Calabria, Ralph, Campeau, Louis-Charles, Campos, Kevin R., Chen, Wenyong, Dalby, Stephen M., Davis, Tyler A., DiRocco, Daniel A., Hyde, Alan M., Kassim, Amude M., Larsen, Mona Utne, Liu, Guiquan, Maligres, Peter E., Moment, Aaron, Peng, Feng, Ruck, Rebecca T., Shevlin, Michael, Simmons, Bryon L., Song, Zhiguo Jake, Tan, Lushi, Wright, Timothy J., Zultanski, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261776/
https://www.ncbi.nlm.nih.gov/pubmed/34276931
http://dx.doi.org/10.1039/d1sc01978c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261776/
https://www.ncbi.nlm.nih.gov/pubmed/34276931
http://dx.doi.org/10.1039/d1sc01978c

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