Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

BACKGROUND: Apatinib, a novel vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, has been approved for the treatment of metastatic gastric cancer and other tumors. Apatinib exerts antiproliferative and proapoptotic effects in different kinds of cancer cells. However,...

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Detalles Bibliográficos
Autores principales: Wang, Yu-Ming, Xu, Xin, Tang, Jian, Sun, Zhi-Yong, Fu, Yu-Jie, Zhao, Xiao-Jing, Ma, Xiu-Mei, Ye, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261945/
https://www.ncbi.nlm.nih.gov/pubmed/34229754
http://dx.doi.org/10.1186/s13578-021-00640-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261945/
https://www.ncbi.nlm.nih.gov/pubmed/34229754
http://dx.doi.org/10.1186/s13578-021-00640-2

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