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Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

BACKGROUND: Apatinib, a novel vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, has been approved for the treatment of metastatic gastric cancer and other tumors. Apatinib exerts antiproliferative and proapoptotic effects in different kinds of cancer cells. However,...

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Detalles Bibliográficos
Autores principales:	Wang, Yu-Ming, Xu, Xin, Tang, Jian, Sun, Zhi-Yong, Fu, Yu-Jie, Zhao, Xiao-Jing, Ma, Xiu-Mei, Ye, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261945/ https://www.ncbi.nlm.nih.gov/pubmed/34229754 http://dx.doi.org/10.1186/s13578-021-00640-2

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