Notch1 Deficiency Induces Tumor Cell Accumulation Inside the Bronchiolar Lumen and Increases TAZ Expression in an Autochthonous Kras (LSL-G12V) Driven Lung Cancer Mouse Model

Purpose: Abrogation of Notch signaling, which is pivotal for lung development and pulmonary epithelial cell fate decisions was shown to be involved in the aggressiveness and the differentiation of lung carcinomas. Additionally, the transcription factors YAP and TAZ which are involved in the Hippo pa...

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Detalles Bibliográficos
Autores principales: Meder, Lydia, Florin, Alexandra, Ozretić, Luka, Nill, Marieke, Koker, Mirjam, Meemboor, Sonja, Radtke, Freddy, Diehl, Linda, Ullrich, Roland T., Odenthal, Margarete, Büttner, Reinhard, Heukamp, Lukas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Society Journal Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262161/
https://www.ncbi.nlm.nih.gov/pubmed/34257546
http://dx.doi.org/10.3389/pore.2021.596522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262161/
https://www.ncbi.nlm.nih.gov/pubmed/34257546
http://dx.doi.org/10.3389/pore.2021.596522

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