Cargando…

TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy

TIGIT is a recently identified coinhibitory receptor that is upregulated in the setting of cancer and functionally contributes to the impairment of antitumor immunity. However, its role during sepsis is unknown. Because patients with cancer are 10 times more likely to die of sepsis than previously h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wenxiao, Anyalebechi, Jerome C., Ramonell, Kimberly M., Chen, Ching-wen, Xie, Jianfeng, Liang, Zhe, Chihade, Deena B., Otani, Shunsuke, Coopersmith, Craig M., Ford, Mandy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262279/ https://www.ncbi.nlm.nih.gov/pubmed/34100383 http://dx.doi.org/10.1172/jci.insight.139823

Ejemplares similares

The IL-27 receptor regulates TIGIT on memory CD4(+) T cells during sepsis
por: Morrow, Kristen N., et al.
Publicado: (2021)

Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts
por: Sun, Yini, et al.
Publicado: (2021)

Increased mortality in CD43-deficient mice during sepsis
por: Fay, Katherine T., et al.
Publicado: (2018)

Critical illness and the role of the microbiome
por: Otani, Shunsuke, et al.
Publicado: (2018)

Pre-existing malignancy results in increased prevalence of distinct populations of CD4(+) T cells during sepsis
por: Xie, Jianfeng, et al.
Publicado: (2018)

CXCR4 blockade decreases CD4(+) T cell exhaustion and improves survival in a murine model of polymicrobial sepsis
por: Ramonell, Kimberly M., et al.
Publicado: (2017)

Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis
por: Klingensmith, Nathan J., et al.
Publicado: (2022)

IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis
por: Morrow, Kristen N., et al.
Publicado: (2019)

Gut integrity in critical illness
por: Otani, Shunsuke, et al.
Publicado: (2019)

Murine Lung Cancer Increases CD4+ T Cell Apoptosis and Decreases Gut Proliferative Capacity in Sepsis
por: Lyons, John D., et al.
Publicado: (2016)

Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis
por: Margoles, Lindsay M., et al.
Publicado: (2016)

Getting older can be exhausting
por: Mittal, Rohit, et al.
Publicado: (2014)

TIGIT in cancer immunotherapy
por: Chauvin, Joe-Marc, et al.
Publicado: (2020)

The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients
por: Lat, Ishaq, et al.
Publicado: (2021)

The small heat shock protein HSPB1 protects mice from sepsis
por: Breed, Elise R., et al.
Publicado: (2018)

TIGIT-based immunotherapeutics in lung cancer
por: Patel, Akshay J, et al.
Publicado: (2023)

Phenotypic T Cell Exhaustion in a Murine Model of Bacterial Infection in the Setting of Pre-Existing Malignancy
por: Mittal, Rohit, et al.
Publicado: (2014)

Impact of chronic alcohol exposure on conventional and regulatory murine T cell subsets
por: Paterson, Cameron W., et al.
Publicado: (2023)

DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease
por: Jacobs, Marleen E, et al.
Publicado: (2020)

TIGIT: A promising target to overcome the barrier of immunotherapy in hematological malignancies
por: Jin, Shenhe, et al.
Publicado: (2022)

Dynamic Expressions of TIGIT on Splenic T Cells and TIGIT-Mediated Splenic T Cell Dysfunction of Mice With Chronic Toxoplasma gondii Infection
por: Li, Haoran, et al.
Publicado: (2021)

The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients
por: Lat, Ishaq, et al.
Publicado: (2021)

Mechanisms of TIGIT-driven immune suppression in cancer
por: Kurtulus, Sema, et al.
Publicado: (2014)

Expression of the immune checkpoint receptor TIGIT in seminoma
por: Hinsch, Andrea, et al.
Publicado: (2019)

Update in TIGIT Immune-Checkpoint Role in Cancer
por: Annese, Tiziana, et al.
Publicado: (2022)

TIGIT in Lung Cancer: Potential Theranostic Implications
por: Pescia, Carlo, et al.
Publicado: (2023)

TIGIT Can Exert Immunosuppressive Effects on CD8(+) T Cells by the CD155/TIGIT Signaling Pathway for Hepatocellular Carcinoma In Vitro
por: Zhang, Changkun, et al.
Publicado: (2020)

The Efficacy and Safety of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease
por: Tang, Hui, et al.
Publicado: (2021)

Dysregulation of neutrophil death in sepsis
por: Zhu, Cheng-long, et al.
Publicado: (2022)

TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
por: Brauneck, Franziska, et al.
Publicado: (2022)

Evaluation of New and Preexisting Epiretinal Membranes Following Glaucoma Filtration Surgery
por: Aoki, Ryota, et al.
Publicado: (2023)

Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study
por: Zhou, Dandan, et al.
Publicado: (2021)

Association Between Preexisting Heart Failure With Reduced Ejection Fraction and Fluid Administration Among Patients With Sepsis
por: Powell, Rachel E., et al.
Publicado: (2022)

The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities*
por: Deutschman, Clifford S., et al.
Publicado: (2020)

The surviving sepsis campaign: basic/translational science research priorities
por: Deutschman, Clifford S., et al.
Publicado: (2020)

Preregistration of Analyses of Preexisting Data
por: Mertens, Gaëtan, et al.
Publicado: (2019)

Preexisting Conditions That Kill Us
por: Hanna-Attisha, Mona, et al.
Publicado: (2021)

Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer
por: Blessin, Niclas C., et al.
Publicado: (2019)

Expression of the immune checkpoint receptor TIGIT in Hodgkin’s lymphoma
por: Li, Wenchao, et al.
Publicado: (2018)

Targeting the “PVR–TIGIT axis” with immune checkpoint therapies
por: Gorvel, Laurent, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hvf9f0h8vcl3jpala7bbf8liuu