Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor-initiating cells

Similar to tumor-initiating cells (TICs), minimal residual disease (MRD) is capable of reinitiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multiregion transcriptomics...

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Detalles Bibliográficos
Autores principales: Artibani, Mara, Masuda, Kenta, Hu, Zhiyuan, Rauher, Pascal C., Mallett, Garry, Wietek, Nina, Morotti, Matteo, Chong, Kay, KaramiNejadRanjbar, Mohammad, Zois, Christos E., Dhar, Sunanda, El-Sahhar, Salma, Campo, Leticia, Blagden, Sarah P., Damato, Stephen, Pathiraja, Pubudu N., Nicum, Shibani, Gleeson, Fergus, Laios, Alexandros, Alsaadi, Abdulkhaliq, Santana Gonzalez, Laura, Motohara, Takeshi, Albukhari, Ashwag, Lu, Zhen, Bast, Robert C., Harris, Adrian L., Ejsing, Christer S., Klemm, Robin W., Yau, Christopher, Sauka-Spengler, Tatjana, Ahmed, Ahmed Ashour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262282/
https://www.ncbi.nlm.nih.gov/pubmed/33945502
http://dx.doi.org/10.1172/jci.insight.147929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262282/
https://www.ncbi.nlm.nih.gov/pubmed/33945502
http://dx.doi.org/10.1172/jci.insight.147929

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