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Restoration of proximal tubule flow–activated transport prevents cyst growth in polycystic kidney disease
Flow-activated Na(+) and HCO(3)(–) transport in kidney proximal tubules (PT) underlies relatively constant fractional reabsorption during changes in glomerular filtration rate (GFR) or glomerulotubular balance (GTB). In view of hypothesized connections of epithelial cilia to flow sensing, we examine...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262298/ https://www.ncbi.nlm.nih.gov/pubmed/33886508 http://dx.doi.org/10.1172/jci.insight.146041 |