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Restoration of proximal tubule flow–activated transport prevents cyst growth in polycystic kidney disease

Flow-activated Na(+) and HCO(3)(–) transport in kidney proximal tubules (PT) underlies relatively constant fractional reabsorption during changes in glomerular filtration rate (GFR) or glomerulotubular balance (GTB). In view of hypothesized connections of epithelial cilia to flow sensing, we examine...

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Detalles Bibliográficos
Autores principales:	Du, Zhaopeng, Tian, Xin, Ma, Ming, Somlo, Stefan, Weinstein, Alan M., Wang, Tong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262298/ https://www.ncbi.nlm.nih.gov/pubmed/33886508 http://dx.doi.org/10.1172/jci.insight.146041

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