Coordination of asparagine uptake and asparagine synthetase expression modulates CD8(+) T cell activation

T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated lymphocytes are met, in part, by upregulation of cell surface transporters and enhanced uptake of amino acid...

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Detalles Bibliográficos
Autores principales: Hope, Helen Carrasco, Brownlie, Rebecca J., Fife, Christopher M., Steele, Lynette, Lorger, Mihaela, Salmond, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262305/
https://www.ncbi.nlm.nih.gov/pubmed/33822775
http://dx.doi.org/10.1172/jci.insight.137761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262305/
https://www.ncbi.nlm.nih.gov/pubmed/33822775
http://dx.doi.org/10.1172/jci.insight.137761

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