Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration

The microtubule (MT) cytoskeleton plays a critical role in axon growth and guidance. Here, we identify the MT-severing enzyme fidgetin-like 2 (FL2) as a negative regulator of axon regeneration and a therapeutic target for promoting nerve regeneration after injury. Genetic knockout of FL2 in cultured...

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Detalles Bibliográficos
Autores principales: Baker, Lisa, Tar, Moses, Kramer, Adam H., Villegas, Guillermo A., Charafeddine, Rabab A., Vafaeva, Olga, Nacharaju, Parimala, Friedman, Joel, Davies, Kelvin P., Sharp, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262307/
https://www.ncbi.nlm.nih.gov/pubmed/33872220
http://dx.doi.org/10.1172/jci.insight.138484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262307/
https://www.ncbi.nlm.nih.gov/pubmed/33872220
http://dx.doi.org/10.1172/jci.insight.138484

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