Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations

Lipin 1 is a bifunctional protein that is a transcriptional regulator and has phosphatidic acid (PA) phosphohydrolase activity, which dephosphorylates PA to generate diacylglycerol. Human lipin 1 mutations lead to episodic rhabdomyolysis, and some affected patients exhibit cardiac abnormalities, inc...

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Detalles Bibliográficos
Autores principales: Chambers, Kari T., Cooper, Michael A., Swearingen, Alison R., Brookheart, Rita T., Schweitzer, George G., Weinheimer, Carla J., Kovacs, Attila, Koves, Timothy R., Muoio, Deborah M., McCommis, Kyle S., Finck, Brian N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262319/
https://www.ncbi.nlm.nih.gov/pubmed/33986192
http://dx.doi.org/10.1172/jci.insight.134340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262319/
https://www.ncbi.nlm.nih.gov/pubmed/33986192
http://dx.doi.org/10.1172/jci.insight.134340

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