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Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus

Extensive activation of glial cells during a latent period has been well documented in various animal models of epilepsy. However, it remains unclear whether activated glial cells contribute to epileptogenesis, i.e., the chronically persistent process leading to epilepsy. Particularly, it is not cle...

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Detalles Bibliográficos
Autores principales: Sano, Fumikazu, Shigetomi, Eiji, Shinozaki, Youichi, Tsuzukiyama, Haruka, Saito, Kozo, Mikoshiba, Katsuhiko, Horiuchi, Hiroshi, Cheung, Dennis Lawrence, Nabekura, Junichi, Sugita, Kanji, Aihara, Masao, Koizumi, Schuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262323/
https://www.ncbi.nlm.nih.gov/pubmed/33830944
http://dx.doi.org/10.1172/jci.insight.135391