CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity

Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance remain poorly understood. Here we report CD109/STAT3 axis as crucial for the m...

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Detalles Bibliográficos
Autores principales: Filppu, Pauliina, Tanjore Ramanathan, Jayendrakishore, Granberg, Kirsi J., Gucciardo, Erika, Haapasalo, Hannu, Lehti, Kaisa, Nykter, Matti, Le Joncour, Vadim, Laakkonen, Pirjo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262342/
https://www.ncbi.nlm.nih.gov/pubmed/33986188
http://dx.doi.org/10.1172/jci.insight.141486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262342/
https://www.ncbi.nlm.nih.gov/pubmed/33986188
http://dx.doi.org/10.1172/jci.insight.141486

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