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CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity
Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance remain poorly understood. Here we report CD109/STAT3 axis as crucial for the m...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262342/ https://www.ncbi.nlm.nih.gov/pubmed/33986188 http://dx.doi.org/10.1172/jci.insight.141486 |