Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis

GWAS have shown that the common R325W variant of SLC30A8 (ZnT8) increases the risk of type 2 diabetes (T2D). However, ZnT8 haploinsufficiency is protective against T2D in humans, counterintuitive to earlier work in humans and mouse models. Therefore, whether decreasing ZnT8 activity is beneficial or...

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Detalles Bibliográficos
Autores principales: Xu, Jie, Wijesekara, Nadeeja, Regeenes, Romario, Rijjal, Dana Al, Piro, Anthony L., Song, Youchen, Wu, Anne, Bhattacharjee, Alpana, Liu, Ying, Marzban, Lucy, Rocheleau, Jonathan V., Fraser, Paul E., Dai, Feihan F., Hu, Cheng, Wheeler, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262350/
https://www.ncbi.nlm.nih.gov/pubmed/34027899
http://dx.doi.org/10.1172/jci.insight.143037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262350/
https://www.ncbi.nlm.nih.gov/pubmed/34027899
http://dx.doi.org/10.1172/jci.insight.143037

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