mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation

Using genetically engineered mouse models, this work demonstrates that protein synthesis is essential for efficient urothelial cancer formation and growth but dispensable for bladder homeostasis. Through a candidate gene analysis for translation regulators implicated in this dependency, we discovere...

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Detalles Bibliográficos
Autores principales: Jana, Sujata, Deo, Rucha, Hough, Rowan P., Liu, Yuzhen, Horn, Jessie L., Wright, Jonathan L., Lam, Hung-Ming, Webster, Kevin R., Chiang, Gary G., Sonenberg, Nahum, Hsieh, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262354/
https://www.ncbi.nlm.nih.gov/pubmed/34032633
http://dx.doi.org/10.1172/jci.insight.144920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262354/
https://www.ncbi.nlm.nih.gov/pubmed/34032633
http://dx.doi.org/10.1172/jci.insight.144920

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